Ataxin 1 antibody

Catalog No. ABIN865485

This anti-Ataxin 1 antibody is a Mouse Monoclonal antibody detecting Ataxin 1 in WB, IHC, ELISA, IF and FACS. Suitable for Human.

Quick Overview for Ataxin 1 antibody (ABIN865485)

Target: Ataxin 1 (ATXN1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ataxin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 2F5

Product Details anti-Ataxin 1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ATXN1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF: 1/200 - 1/1000, FC: 1/200-1/400 ELISA: Propose dilution 1/10000. Figure 3: Immunofluorescence

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Ataxin 1

Target: Ataxin 1 (ATXN1)

Alternative Name: ATXN1

Background: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. Synonyms: ATX1, SCA1, D6S504E, ATXN1

Molecular Weight: 87kDa

Gene ID: 6310

Pathways: Synaptic Membrane